Apc ELISA Kit for Mouse(Mus musculus) | EIAab.comApc ELISA Kit for Mouse(Mus musculus)

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Apc (Gene name),

Adenomatous polyposis coli protein (Protein name ), APC_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Apc;

Protein name:

Adenomatous polyposis coli protein(Protein APC;mAPC);

Alternative:

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Forms homooligomers and heterooligomers with APC2. Interacts with PDZ domains of DLG1 and DLG3. Associates with catenins. Binds axin. Interacts with MAPRE2 and MAPRE3 (via C-terminus). Found in a complex consisting of ARHGEF4, APC and CTNNB1. Interacts with ARHGEF4 (via N-terminus) (By similarity). Interacts with MAPRE1 (via C-terminus); probably required for APC targeting to the growing microtubule plus ends. Interacts with DIAPH1 and DIAPH2. Interacts with SCRIB; may mediate targeting to adherens junctions of epithelial cells. Interacts with SPATA13 (via N-terminus and SH3 domain). Interacts with ASAP1 (via SH3 domain) (By similarity). Found in a complex composed of MACF1, APC, AXIN1, CTNNB1 and GSK3B.

Function:

Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration (By similarity). Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization.

Subcellular Location:

Cell junction adherens junction Cytoplasm cytoskeleton Cell projection lamellipodium Cell projection ruffle membrane Cytoplasm Cell membrane Associated with the microtubule network at the growing distal tip of microtubules. Accumulates in the lamellipodium and ruffle membrane in response to hepatocyte growth factor (HGF) treatment. The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosophorylated form to the cell membrane.

Protein Attributes:

Sequence length:

2845

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SARPSQIPTP | VSTNTKKRDS | KTDITESSGA | QSPKRHSGSY | LVTSV

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q61315

Pfam:

PF05972

UniGene:

Mm.384171

SMR:

Q61315

Uniprot:

Q61315

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ELISA Kit for Mouse Protein APC

Cat.:

E10944m

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Manual:

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MSDS:

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Packing:

96T

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ELISA Kit for Mouse Protein APC

Cat.:

E10944h

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Manual:

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Packing:

96T

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ELISA Kit for Mouse Protein APC

Cat.:

E10944r

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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CLIA Kit for Mouse Protein APC

Cat.:

U10944h

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Mouse Protein APC

Cat.:

U10944m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Mouse Protein APC

Cat.:

U10944r

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Mouse Protein APC

Cat.:

P10944Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse Protein APC

Protein for Mouse Protein APC

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene."
Su L.-K. , Kinzler K.W. , Vogelstein B. , Preisinger A.C. , Moser A.R. , Luongo C. , Gould K.A. , Dove W.F.
Science256:668-670(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);VARIANTS
strain: C57BL/6J.
strain: CAST/Ei.
tissue: Brain.
2.

Su L.-K. , Kinzler K.W. , Vogelstein B. , Preisinger A.C. , Moser A.R. , Luongo C. , Gould K.A. , Dove W.F.
Science256:1114-1114(1992)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
3.

"The murine APC gene: alternative splicing of 5' untranslated region segments."
Dicker F. , Lambertz S. , Reitmair A. , Ballhausen W.G.
Submitted (1993-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-45
strain: BALB/c.
tissue: Liver.
4.

Lubec G. , Sunyer B. , Chen W.-Q.
Submitted (2009-01) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 1795-1810;IDENTIFICATION BY MASS SPECTROMETRY
strain: OF1.
tissue: Hippocampus.
5.

"APC gene messenger RNA: novel isoforms that lack exon 7."
Oshima M. , Sugiyama H. , Kitagawa K. , Taketo M.
Cancer Res.53:5589-5591(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING
6.

"EB1 and APC bind to mDia to stabilize microtubules downstream of Rho and promote cell migration."
Wen Y. , Eng C.H. , Schmoranzer J. , Cabrera-Poch N. , Morris E.J.S. , Chen M. , Wallar B.J. , Alberts A.S. , Gundersen G.G.
Nat. Cell Biol.6:820-830(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DIAPH1; DIAPH2 AND MAPRE1
7.

"Human scribble, a novel tumor suppressor identified as a target of high-risk HPV E6 for ubiquitin-mediated degradation, interacts with adenomatous polyposis coli."
Takizawa S. , Nagasaka K. , Nakagawa S. , Yano T. , Nakagawa K. , Yasugi T. , Takeuchi T. , Kanda T. , Huibregtse J.M. , Akiyama T. , Taketani Y.
Genes Cells11:453-464(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SCRIB
8.

"The adenomatous polyposis coli-associated exchange factors Asef and Asef2 are required for adenoma formation in Apc(Min/+)mice."
Kawasaki Y. , Tsuji S. , Muroya K. , Furukawa S. , Shibata Y. , Okuno M. , Ohwada S. , Akiyama T.
EMBO Rep.10:1355-1362(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION

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